Carbapenems: do they have a future?
نویسندگان
چکیده
منابع مشابه
Carbapenems: past, present, and future.
In this review, we summarize the current "state of the art" of carbapenem antibiotics and their role in our antimicrobial armamentarium. Among the β-lactams currently available, carbapenems are unique because they are relatively resistant to hydrolysis by most β-lactamases, in some cases act as "slow substrates" or inhibitors of β-lactamases, and still target penicillin binding proteins. This "...
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Definitions: Beta-lactam antimicrobials are characterized by having a four-membered cyclic amide (beta-lactam ring) as part of their chemical structure (Figure 1) [1]. This broad group includes the penicillins, cephalosporins, carbapenems, and monobactams [1]. All beta-lactams have a similar mechanism of action; they inhibit bacterial cell wall synthesis [1]. Resistance to beta-lactam antimicro...
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ورودعنوان ژورنال:
- Journal of medical microbiology
دوره 60 Pt 9 شماره
صفحات -
تاریخ انتشار 2011